
President (also voiced by Jeff Bennett) for saving Earth from being destroyed by the Invince-a-tron. In the aftermath, Tom and Jerry are rewarded with a Hummer by the U.S. Tom, Jerry and Peep ultimately foil the Invince-a-tron by using a bone to get Spike (also voiced by Frank Welker) into his brain and make it malfunction, destroying it. They manage to stop them, but a gigantic orange vacuum cleaner robot named the “Invince-a-tron” eventually arrives on Earth and begins to suck everyone up with its vacuum. After much calamity and a discovery that Jerry is not the Great Gloop, Tom, Jerry and Peep hijack a flying saucer ( UFO) so that they can get back to Earth and warn everyone about a potential attack by the martians. A green female alien named Peep (voiced by Kathryn Fiore) along with an alien dog Ubu (voiced by Frank Welker) and two more martians (voiced by Jeff Bennett and Tom Kenny) arrive to which Jerry is then taken to the martians' lair where he is mistaken for the “Great Gloop”. During the chase, the duo land onto a rocket ending up at Mars where Tom and Jerry are left behind. Soon, the staff tries to catch Jerry, but figuring that only Tom can catch him, they bring him back to the base and give him a mission to eliminate Jerry.

During the testing of dehydrated food, Jerry knocks over a cup in the process, resulting in the food going all over the place in an explosion.

In the process, Tom and Jerry are caught during the speech (first misunderstood as aliens due to Tom getting hit by green paint backstage) and the staff try to capture them, but only Tom is caught and thrown out. Tom (voiced by Bill Kopp) chases Jerry as usual from their house and across town until they arrive at the "International Space Place", where astronauts Buzz Blister (voiced by Jess Harnell) and Biff Buzzard (voiced by Billy West) are heading to Mars.
